Volume 10 Issue 1
Feb.  2014
Turn off MathJax
Article Contents
Abstract
References
Related Articles
LI Guolie, WANG Yuan, FANG Wenhong, SHEN Jinyu, ZHOU Junfang. Pharmacokinetics and bioavailability of sarafloxacin hydrochloride in Litopenaeus vannamei[J]. South China Fisheries Science, 2014, 10(1): 50-56. DOI: 10.3969/j.issn.2095-0780.2014.01.008
Citation: LI Guolie, WANG Yuan, FANG Wenhong, SHEN Jinyu, ZHOU Junfang. Pharmacokinetics and bioavailability of sarafloxacin hydrochloride in Litopenaeus vannamei[J]. South China Fisheries Science, 2014, 10(1): 50-56. DOI: 10.3969/j.issn.2095-0780.2014.01.008
shu

Pharmacokinetics and bioavailability of sarafloxacin hydrochloride in Litopenaeus vannamei

  • 1.

    Key Lab. of East China Sea & Oceanic Fishery Resources Exploitation and Utilization, Ministry of Agriculture; East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China

  • 2.

    Nanchong Monitoring and Test Center for Agricultural Products Quality, Nanchong 637000, China

  • 3.

    Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China

More Information
  • Received Date: April 27, 2013
  • Revised Date: August 21, 2013
    Graphical Abstract
    • Abstract

  • We investigated the pharmacokinetics and bioavailability of sarafloxacin hydrochloride in Litopenaeus vannamei following intra-sinus injection (10 mg · kg-1) and oral administration (30 mg · kg-1) using the RP-HPLC. The shrimps were kept in seawater with salinity of 33 and at temperature of (28.0±1.0) ℃. The concentration-time curves of haemolymph sarafloxacin hydrochloride after intra-sinus injection and oral adminstration were best described by two-compartment model and two-compartment model with first absorption, respectively. After oral adminstration, the bioavailability (F) of sarafloxacin hydrochloride was 61.6%, and the concentration of sarafloxacin hydrochloride in hepatopancreas was 24.4 and 51.9 times higher than that in hemolymph and muscle, respectively, while the AUC0-t of hepatopancrea was 18.7 and 62.0 times higher than that in hemolymph and muscle, respectively. However, the sarafloxacin hydrochloride was faster eliminated in hepatopancreas and muscle, the reside concentration being less than 0.1 mg · kg-1 in 36 h for muscle and in 5 d for hepatopancreas after oral administration. Since sarafloxacin hydrochloride has good absorption and high bioavailability with faster elimination in hepatopancreas and muscle, it is an ideal antimicrobial agent for prevention and treatment of shrimp bacterial diseases.

    • FullText(HTML)
    • References (25)
  • [1]
    熊建华, 赵永贞, 高永华, 等. 凡纳滨对虾良种培育研究进展[J]. 南方农业学报, 2011, 42(5): 556-561. doi: 10.3969/j.issn.2095-1191.2011.05.025
    [2]
    杨先乐, 郑宗林. 南美白对虾病害流行的新动向及其思考[J]. 淡水渔业, 2005, 35(3): 3-6. doi: 10.3969/j.issn.1000-6907.2005.03.001
    [3]
    沈文英, 阳会军, 尹军霞. 南美白对虾的病害及防治研究现状[J]. 水利渔业, 2004, 24(1): 58-60. doi: 10.3969/j.issn.1003-1278.2004.01.027
    [4]
    WOLFSON J S, HOOPER D C. 最新广谱喹诺酮类抗微生物药[M]. 姜素椿, 宋克, 译. 北京: 人民军医出版社, 1991: 26-45. https://xueshu.baidu.com/usercenter/paper/show?paperid=f92ce1fe2f7442c927fcdd8e719800a6&site=xueshu_se&hitarticle=1
    [5]
    施彬, 沈丽珠. 喹诺酮类兽用新型抗菌剂沙拉沙星的研究进展[J]. 兽药与饲料添加剂, 1999, 4(4): 13-17.
    [6]
    MARTINSEN B, HORSBERG T E, BURKE M. Multiple-dose pharmacokinetic and depletion studies of sarafloxacin in Atlantic salmon, Salmo salar L.[J]. J Fish Dis, 1994, 17(2): 111-122. doi: 10.1111/j.1365-2761.1994.tb00204.x
    [7]
    MARTINSEN B. Single dose kinetic study of sarafloxacin afer intravenous and oral administration of different formulations to Altantic salmon (Salmon salar) held in sea water at 8.5 ℃[J]. Aquaculture, 1993, 118(1/2): 37-47. doi: 10.1016/0044-8486(93)90278-7
    [8]
    MARTINSEN B, HORSBERG T E. Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin and enorfloxacin in Atlantic salmon (Salmo salar) held in sea water at 10 degree C[J]. Antimicrob Agents Ch, 1995, 39(5): 1059-1064. doi: 10.1128/AAC.39.5.1059
    [9]
    HO S P, CHENG C F, WANG W S. Pharmacokinetic and depletion studies of sarafloxacin after oral adminstration to eel (Anguilla anguilla)[J]. J Vet Med Sci, 1999, 61(5): 459-463. doi: 10.1292/jvms.61.459
    [10]
    李彩云, 隆雪明, 扶亚祥, 等. 盐酸沙拉沙星在锦鲤体内的药物动力学研究[J]. 水产科学, 2008, 27(6): 297-301. doi: 10.3969/j.issn.1003-1111.2008.06.008
    [11]
    王大菊, 邱银生, 周诗其, 等. 盐酸沙拉沙星(saraflxoacin)在鸡体内的药动学和生物利用度[J]. 中国兽医学报, 2002, 26(2): 612-614. https://www.doc88.com/p-7764536774466.html
    [12]
    李银生, 佟恒敏. 盐酸沙拉沙星在兔体内的药物动力学及生物利用度研究[J]. 中国兽医杂志, 2001, 37(6): 46-48. doi: 10.3969/j.issn.0529-6005.2001.06.027
    [13]
    丁焕中, 曾振灵, 冯淇辉, 等. 沙拉沙星在猪体内的药动学研究[J]. 畜牧兽医学报, 2002, 33(1): 55-58. doi: 10.3321/j.issn:0366-6964.2002.01.013
    [14]
    GOY M F. Nitric oxide: an inhibitory retrograde modulator in the crustacean heart[J]. Comp Biochem Physiol Part A: Mol Integr Physiol, 2005, 142(2): 151-163. doi: 10.1016/j.cbpb.2005.05.050
    [15]
    李娜, 李健, 王群. 米诺沙星在中国对虾体内的代谢动力学及在养殖系统中的消除[J]. 安徽农业科学, 2008, 36(24) : 10480-10483. doi: 10.3969/j.issn.0517-6611.2008.24.085
    [16]
    房文红, 杨先乐, 周凯. 诺氟沙星在凡纳滨对虾不同组织中处置和消除规律[J]. 水产学报, 2004, 28(增刊): 19-24. https://xueshu.baidu.com/usercenter/paper/show?paperid=8b8c33909726d9d8efeecd9988aa5384&site=xueshu_se&hitarticle=1
    [17]
    FAROONGSARNG D, CHANDUMPAI A, CHIAYVAREESAJJA S, et al. Bioavailability and absorption analysis of oxytetracycline orally administered to the standardized moulting farmed Pacific white shrimp (Penaeus vannamei)[J]. Aquaculture, 2007, 269(1/2/3/4): 89-97. doi: 10.1016/j.aquaculture.2007.04.019
    [18]
    孙贝贝, 胡琳琳, 房文红, 等. 土霉素在斑节对虾体内药代动力学和生物利用度[J]. 中国兽医学报, 2011, 31(11): 1653-1659. https://xueshu.baidu.com/usercenter/paper/show?paperid=14416b71683546495e7050bc226a48cc&site=xueshu_se&hitarticle=1
    [19]
    李正, 杨勇, 杨先乐, 等. 盐酸环丙沙星药液口灌在中华绒螯蟹体内的代谢动力学研究[J]. 水产学报, 2004, 28(增刊): 25-29. https://xueshu.baidu.com/usercenter/paper/show?paperid=f84839abfe856d7ca3ceff2dd8ee7a96&site=xueshu_se&hitarticle=1
    [20]
    REED L A, SIEWICKI T C, SHAH J C, et al. The biopharmaceutics and oral bioavailability of two forms of oxytetracycline to the white shrimp, Litopenaeus setiferus[J]. Aquaculture, 2006, 258(1/2/3/4): 42-54. doi: 10.1016/j.aquaculture.2006.03.029
    [21]
    TYRPENOU A E, LOSSIFIDOU E G, PSOMAS I E, et al. Tissue distribution and depletion of sarafloxacin hydrochloride after in feed administration in gilthead seabream (Sparus aurata L.)[J]. Aquaculture, 2003, 215(1) : 291-300. doi: 10.1016/S0044-8486(02)00367-8
    [22]
    张培旗, 李健, 王群, 等. 磺胺甲基异恶唑在中国明对虾体内的残留和消除规律[J]. 水产科学, 2005, 24(11): 17-20. doi: 10.3969/j.issn.1003-1111.2005.11.006
    [23]
    曹立民, 李健, 刘淇, 等. 凡纳滨对虾摄食诺氟沙星强化卤虫的药代动力学研究[J]. 海洋科学, 2006, (5): 45-51. doi: 10.3969/j.issn.1000-3096.2006.05.010
    [24]
    刘克辛, 韩国柱. 临床药物代谢动力学[M]. 北京: 科学出版社, 2010: 53-54, 173. https://xueshu.baidu.com/usercenter/paper/show?paperid=c5e98aa3886796c7ce7ed9efdffb1aa5&site=xueshu_se&hitarticle=1
    [25]
    王桂枝, 石德时, 毕丁仁, 等. 国产盐酸沙拉沙星体外抑菌活性研究[J]. 华中农业大学学报, 1998, 17(3): 246-251. https://xueshu.baidu.com/usercenter/paper/show?paperid=03a214494c35bda0600674c510e5d46d&site=xueshu_se&hitarticle=1
    • Related Articles

  • Related Articles

    [1]DENG Dong, WEN Yongsen, LIU Xiaokun, LYU Wengang, CHEN Jinglei, CHEN Jingbu. Pharmacokinetics and residual elimination pattern of enrofloxacin and its metabolite ciprofloxacin in Babylonia areolate[J]. South China Fisheries Science, 2024, 20(6): 176-186. DOI: 10.12131/20240152
    [2]ZHU Xuanyi, ZHENG Xiaoting, XING Yifu, HUANG Jianhua, DONG Hongbiao, ZHANG Jiasong. Study on tributyrin enhancing anti periodic high temperature stress ability of gill tissue in Litopenaeus vannamei[J]. South China Fisheries Science, 2024, 20(3): 66-75. DOI: 10.12131/20230246
    [3]FANG Yuan, LI Hui, WANG Libao, WAN Xihe, SHI Wenjun, YANG Zeyu, JIANG Qi, SHEN Hui, HU Runhao, GUAN Xiaoping, YANG Jiaxin. Study on bacterial community structure in rearing water in small greenhouse of Litopenaeus vannamei[J]. South China Fisheries Science, 2023, 19(3): 29-41. DOI: 10.12131/20220205
    [4]TAO Feiyan, PAN Chuang, CHEN Shengjun, HU Xiao, DENG Jianchao, LI Chunsheng, RONG Hui, WANG Yueqi. Microbial analysis of Litopenaeus vannamei during partial freezing storage by Illumina high throughput sequencing[J]. South China Fisheries Science, 2021, 17(2): 104-113. DOI: 10.12131/20200211
    [5]HAN Tianjiao, XU Wujie, XU Yu, WEN Guoliang, HU Xiaojuan, SU Haochang, CAO Yucheng. Effect of stopping adding brown sugar on water quality and nitrogen budget in biofloc systems cultured with Litopenaeus vannamei[J]. South China Fisheries Science, 2020, 16(6): 81-88. DOI: 10.12131/20200052
    [6]HUANG Xiaoshuai, XU Yu, HU Xiaojuan, XU Wujie, SU Haochang, WEN Guoliang, YANG Keng, CAO Yucheng. Genetic diversity analysis of first filial generation of seven introduced Litopenaeus vannamei populations using microsatellite DNA markers[J]. South China Fisheries Science, 2019, 15(1): 54-62. DOI: 10.12131/20180135
    [7]PENG Yuanhuai, WANG Sheng, LI Chengpeng, CHEN Bitao, HUANG Yingli. Recycling of waste hydrochloric acid during chitin production process from Litopenaeus vannamei processing leftover[J]. South China Fisheries Science, 2017, 13(1): 104-109. DOI: 10.3969/j.issn.2095-0780.2017.01.013
    [8]FENG Jing-bin, JIA Xiao-ping. Pharmacokinetics of florfenicol in tilapia at two water temperatures[J]. South China Fisheries Science, 2008, 4(4): 49-54.
    [9]YE Le, LIN Hei-zhe, LI Zhuo-jia, WU Kai-chang, WEN Guo-liang, MA Zhi-ming, ZHU Chang-fu. The effect of feeding frequency on growth of Litopenaeus vannamei (Boone) and water quality[J]. South China Fisheries Science, 2005, 1(4): 55-59.
    [10]LI Zhuo-jia, LIN Liang, YANG Ying-ying, LIN Xiao-tao. Effect of Bacillus commercial probiotic on intestinal microflora of white shrimp, Litopenaeus vannamei[J]. South China Fisheries Science, 2005, 1(3): 54-59.

  • Cited by

    Periodical cited type(3)

    1. 毕竞男，谢国驷，梁成伟. 海水养殖蟹类寄生虫病研究进展. 动物医学进展. 2024(08): 104-108 .
    2. 黄智康，江世贵，周发林，黄建华，杨其彬，姜松，李运东，杨丽诗. 基于InDel标记的斑节对虾早期性别鉴定方法的建立. 南方水产科学. 2020(03): 113-118 . 本站查看
    3. 李楠英，房文红，王元，马清扬，李新苍，赵姝，符贵红，周俊芳. 虾苗场3种重要病原同步定量PCR检测技术的建立. 海洋渔业. 2020(03): 375-384 .

    Other cited types(3)

Catalog

    Get Citation
    PDF
    XML
    Article views (3089) PDF downloads (1732) Cited by(6)
    Related

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return