Volume 21 Issue 2
Apr.  2025
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MA Wenyu, YANG Wei, QIN Xiaoming, CAO Wenhong, LIN Haisheng. Ameliorative effect of oyster enzymatic products on glucocorticoid-induced osteoporosis in rats[J]. South China Fisheries Science, 2025, 21(2): 182-190. DOI: 10.12131/20240223
Citation: MA Wenyu, YANG Wei, QIN Xiaoming, CAO Wenhong, LIN Haisheng. Ameliorative effect of oyster enzymatic products on glucocorticoid-induced osteoporosis in rats[J]. South China Fisheries Science, 2025, 21(2): 182-190. DOI: 10.12131/20240223
shu

Ameliorative effect of oyster enzymatic products on glucocorticoid-induced osteoporosis in rats

  • 1 .

    School of Food Science and Technology, Guangdong Ocean University/National R&D Center for Shellfish Processing Technology (Zhanjiang)/Key Research Laboratory of Aquatic Products Processing and Safety of Guangdong Province/Marine Bioproducts Engineering Laboratory of Guangdong Province/Guangdong Food Engineering and Technology Research Center/Guangdong Provincial Aquatic Prepared Processing and Quality Control Engineering Technology Center, Zhanjiang 524088, China

  • 2 .

    Shenzhen Research Institute, Guangdong Ocean University, Shenzhen 518120, China

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  • Received Date: September 21, 2024
  • Revised Date: December 04, 2024
  • Accepted Date: January 17, 2025
  • Available Online: January 23, 2025
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    • Abstract

  • Oyster has a variety of biological activities, and with the intensive research on the development of its activities, the great potential for the improvement of osteoporosis has been found. In this paper, the oyster enzymatic products (OP) were used to investigate their mitigating effects on glucocorticoid-type osteoporosis. A dexamethasone-induced glucocorticoids osteoporosis (GIOP) model was established, and different doses of OP were used to evaluate the mitigating effects of OP on the osteoporosis in rats in terms of serum biochemical indexes, Micro-CT, three-dimensional reconstruction, and histopathological sections. The results show that compared with the model group, the serum content of osteoprotegerin, Type I procollagen amino-terminal peptide and testosterone, which are the osteoclast markers, increased by an average of 13.67%, 11.51% and 17.80% in the low, medium and high dose groups, respectively (p<0.05); but the serum content of matrix metalloproteinases, histone K and anti-tartrate acid phosphatase, which are the osteoclast markers, decreased by 15.44%, 31.20% and 14.43%, respectively (p<0.05). The results of bone densitometry and histopathological analysis of Micro-CT and femur indicate that compared with those of the model group, the bone mineral density, the percentage of bone trabecular area and the area of bone salt deposition in the high-dose group increased by 56.31%, 18.59% and 22.51%, respectively (p<0.05). In conclusion, OP can accelerate the formation of new bone by increasing the ability of osteoblasts to synthesize collagen, decrease the rate of bone matrix degradation and bone metabolism, decrease the loss of bone mass, increase the level of sex hormones, increase the BMD, bone volume fraction, enhance the ability of bone to deposit bone calcium salts in rats, thus improve the symptoms of glucocorticoid-induced osteoporosis induced by dexamethasone.

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