Volume 15 Issue 5
Oct.  2019
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YANG Faming, LIN Haisheng, QIN Xiaoming, ZHANG Chaohua, CAO Wenhong, GAO Jialong. Effect of enzymatic hydrolysis from mantle of pearl oyster on skin wound healing[J]. South China Fisheries Science, 2019, 15(5): 92-98. DOI: 10.12131/20190079
Citation: YANG Faming, LIN Haisheng, QIN Xiaoming, ZHANG Chaohua, CAO Wenhong, GAO Jialong. Effect of enzymatic hydrolysis from mantle of pearl oyster on skin wound healing[J]. South China Fisheries Science, 2019, 15(5): 92-98. DOI: 10.12131/20190079
shu

Effect of enzymatic hydrolysis from mantle of pearl oyster on skin wound healing

  • 1.

    College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China

  • 2.

    National Research and Development Branch Center for Shellfish Processing (Zhanjiang), Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Provincial Engineering Laboratory for Marine Biological Products, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Zhanjiang 524088, China

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  • Received Date: April 04, 2019
  • Revised Date: June 09, 2019
  • Accepted Date: July 21, 2019
  • Available Online: July 23, 2019
    Graphical Abstract
    • Abstract

  • In order to promote the high value utilization of pearl oyster (Pinctada martensii), we were determined explore the antibacterial activity and procoagulant activity of enzymatic hydrolysis from its mantle (EHM), and the effects of EHM on open wound healing of skin of mice. Results showed that EHM possessed of procoagulant activity in mice but had no antibacterial activity against 13 tested strains. Compared with the negative control group, the healing rate of wound of mice increased significantly after skin application with EHM for 6 d (P<0.05), but there was no significant difference with comparison with the positive control group (P>0.05). The healing rate was 100% on 14th day for the drug group, and the scar contraction rate was significantly higher than that of the negative control group (P<0.05). Biochemical indicators test indicated that EHM had significant inhibitation effect on inflammatory factor IL-6 (P<0.05); compared with the negative control group, it could promote IL-10 secretion in wound tissues significantly (P<0.05), but there was no significant difference in FGF-2 content in skin tissue of the drug groups (P>0.05), and EGF content in the positive control group was significantly higher than that in the other groups (P<0.05). Howerer, there was no significant difference in the contents of FGF-2 and EGF between the drug groups (P<0.05). In summary, EHM has procoagulant, anti-inflammatory and promotional effects, which can accelerate the open wound healing of soft tissue in mice and has a certain inhibitory effect on superficial scar hyperplasia.

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