Citation: | YANG Hongliang, HUANG Ke, LI Liudong, KE Changliang, ZHAO Donghao, LIU Qi, MO Mengsong, CHEN Jiewen. Exposure assessment on chloramphenicol residues in commercially available shellfish in 2015–2017[J]. South China Fisheries Science, 2019, 15(1): 93-99. DOI: 10.12131/20180089 |
In order to investigate the chloramphenicol residues in commercially available shellfish and to assess their exposure, we collected 300 shellfish samples which were determined by LC-MS/MS and analyzed by @risk software using Monte Carlo method. The daily intake and estimated dietary exposure were simulated, and the margins of exposure were calculated. The results show that 33 samples were determined to have chloramphenicol residues in 2015. The MOE value of the general population was 15 361, presenting a medium risk (according to the evaluation criteria of the Canadian Ministry of Health). The MOE value of the high exposure population was 5 208, also presenting a medium risk. In 2016, three samples were determined to have chloramphenicol residues. The MOE value of the general population was 10 3627, presenting a medium risk. The MOE value of the high exposure population was 34 722, presenting a medium risk. In 2017, no samples were determined to have chloramphenicol residues, presenting no risk.
[1] |
IARC. IARC monograhs on the evaluation of carcinogenic risk to humans[EB/OL]. (2018-04-18) [2018-04-20]. http://monographs.iarc.fr/ENG/Classification/latest_classif.php.
|
[2] |
TIAN L, BAYEN S. Thermal degradation of chloramphenicol in model solutions, spiked tissues and incurred samples[J]. Food Chem, 2018, 248: 230-237. doi: 10.1016/j.foodchem.2017.12.043
|
[3] |
KIKUCHI H, SAKAI T, TESHIMA R, et al. Total determination of chloramphenicol residues in foods by liquid chromatography-tandem mass spectrometry[J]. Food Chem, 2017, 230: 589-593. doi: 10.1016/j.foodchem.2017.03.071
|
[4] |
SAMANIDOU V, KEHAGIA M, KABIR A, et al. Matrix molecularly imprinted mesoporous sol-gel sorbent for efficient solid-phase extraction of chloramphenicol from milk[J]. Analytica Chimica Acta, 2016, 914: 62-74. doi: 10.1016/j.aca.2016.02.003
|
[5] |
陆威达. 上海市动物性食品中氯霉素残留及人群暴露的研究[D]. 上海: 复旦大学, 2013: 6-7.
|
[6] |
国家药典委员会. 中华人民共和国药典临床用药须知[M]. 北京: 中国医药科技出版社, 2011: 718-721.
|
[7] |
中华人民共和国农业部公告第235号——动物性食品中兽药最高残留限量[EB/OL]. (2002-12-24) [2015-12-01]. http://www.moa.gov.cn/govpublic/SYJ/201006/t20100606_1535491.htm.
|
[8] |
王君, 吴永宁. 遗传毒性致癌物风险评估的新技术[J]. 国外医学: 卫生学分册, 2009, 36(6): 369-371.
|
[9] |
王敏娟, 聂晓玲, 程国霞, 等. 陕西省淡水鱼中孔雀石绿的污染调查及居民膳食暴露评估[J]. 卫生研究, 2015, 44(6): 965-969.
|
[10] |
NUGRAHA A, KHOTIMAH K, RIETJENS I M. Risk assessment of aflatoxin B1 exposure from maize and peanut consumption in Indonesia using the margin of exposure and liver cancer risk estimation approaches[J]. Food Chem Toxicol, 2018, 113: 134-144. doi: 10.1016/j.fct.2018.01.036
|
[11] |
THOMPSON C M, KIRMAN C R, HAYS S M. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium[J]. J Appl Toxicol, 2017, 38(3): 351-365.
|
[12] |
OKARU A O, RULLMANN A, FARAH A, et al. Comparative oesophageal cancer risk assessment of hot beverage consumption (coffee, mate and tea): the margin of exposure of PAH vs very hot temperatures[J]. BMC Cancer, 2018, 18(1): 236. doi: 10.1186/s12885-018-4060-z
|
[13] |
段文佳, 张晓燕, 周德庆. 水产品来源的甲醛膳食暴露评估初步研究[J]. 食品工业科技, 2012, 33(3): 305-308, 421.
|
[14] |
袁玉伟, 王强, 朱加虹, 等. 食品中农药残留的风险评估研究进展[J]. 浙江农业学报, 2011, 23(2): 394-399. doi: 10.3969/j.issn.1004-1524.2011.02.039
|
[15] |
周德庆. 水产品安全风险评估理论与案例[M]. 青岛: 中国海洋大学出版社, 2013: 221.
|
[16] |
王阳, 徐明芳, 耿梦梦, 等. 基于Monte Carlo模拟法对水源水体中微囊藻毒素的健康风险评估[J]. 环境科学, 2017(5): 1842-1851.
|
[17] |
段文佳, 周德庆, 张瑞玲. 基于蒙特卡罗的水产品中甲醛定量风险评估[J]. 中国农学通报, 2011, 27(23): 65-69.
|
[18] |
GEMS/Food-WHO. Reliable evaluation of low-level contaminant of food, workshop in the frame of GEMS/Food-EURO[R]. Kulmbach, Germany: WHO, 1995.
|
[19] |
Tolerance Reassessment Advisory Committee. Regulating risk from undetected residues in food[R]. Wsahington D.C., USA: Office of pesticide programs. Environmental Protection Agency, 1998.
|
[20] |
白新明. 蔬菜农药残留对人体健康急性风险概率评估研究[J]. 食品科学, 2014, 35(5): 208-212.
|
[21] |
张易. 茶叶中水溶性氟化物安全风险分析及安徽茶园土壤−茶树系统氟富集特性[D]. 合肥: 安徽农业大学, 2013: 14.
|
[22] |
刘畅. 食品中兽药残留高通量筛查与检测平台的建立及膳食暴露评估研究[D]. 上海: 第二军医大学, 2013: 100-125.
|
[23] |
WHO. GEMS/Food cluster diets 2013[EB/OL]. (2015-01-12) [2015-12-01]. https://extranet.who.int/sree/Reports?op=vs&path=/WHO_HQ_Reports/G7/PROD/EXT/GEMS_cluster_diets_2012&userid=G7_ro&password=inetsoft123.
|
[24] |
NING J, CUI X Y, KONG X N, et al. Risk assessment of genotoxic and carcinogenic alkenylbenzenes in botanical containing products present on the Chinese market[J]. Food Chem Toxicol, 2018, 115: 344-357. doi: 10.1016/j.fct.2018.03.020
|
[25] |
FAO, WHO. Specifications for the identity and purity of food additives and their toxicological evaluation: some antibiotics (twelfth report of the Joint FAO/WHO expert committee on food additives)[R]. Geneva: FAO/WHO, 1969.
|
[26] |
EUROPEAN UNION. Commission Decision 2003/181/EC, March 13, 2003, amending decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin[J]. Official J EU, 2003, 71: 17-18.
|
[27] |
翟凤英, 杨晓光. 中国居民营养与健康状况调查报告之二2002膳食与营养素摄入状况[M]. 北京: 人民卫生出版社, 2006: 23.
|
[28] |
张永慧, 马文军. 广东省居民膳食营养与健康状况十年变化分析[M]. 北京: 中国标准出版社, 2016: 33.
|
[29] |
常继乐, 王宇. 中国居民营养与健康状况监测2010-2013年综合报告[M]. 北京: 北京大学医学出版社, 2016: 30.
|
[30] |
唐洪磊, 郭英, 孟祥周, 等. 广东省沿海城市居民膳食结构及食物污染状况的调研——对持久性卤代烃和重金属的人体暴露水平评价[J]. 农业环境科学学报, 2009, 28(2): 329-336. doi: 10.3321/j.issn:1672-2043.2009.02.020
|
[31] |
Van DEN BERG S L, ALHUSAINY W, RESTANI P, et al. Chemical analysis of estragole in fennel based teas and associated safety assessment using the margin of exposure (MOE) approach[J]. Food Chem Toxicol, 2014, 65: 147-154. doi: 10.1016/j.fct.2013.12.035
|
[1] | LUO Jing, LI Min, ZHANG Ying, LIU Yan, GUAN Zhiqiang. Effect of different drying methods on volatile components of tilapia fillets analyzed by electronic nose combined with GC-MS[J]. South China Fisheries Science, 2022, 18(1): 135-143. DOI: 10.12131/20210098 |
[2] | LI Laihao, SUN Bolun, ZHAO Donghao. Research progress in detection and preparation methods for tetrodotoxin[J]. South China Fisheries Science, 2018, 14(3): 126-132. DOI: 10.3969/j.issn.2095-0780.2018.03.016 |
[3] | CHEN Kang, DAI Zhiyuan, SHEN Qing, HUANG Yaowen. Extraction of phospholipid from Euphausia superba by response surface method and determination of phospholipid molecular species[J]. South China Fisheries Science, 2017, 13(3): 104-112. DOI: 10.3969/j.issn.2095-0780.2017.03.014 |
[4] | WANG Zhengbin, LIU Yongtao, AI Xiaohui, YANG Tao, LIU Tianqiang. Microbiological inhibition method for determination of colistin residues in muscles of aquatic products[J]. South China Fisheries Science, 2016, 12(3): 98-105. DOI: 10.3969/j.issn.2095-0780.2016.03.013 |
[5] | WEI Ya, ZHAO Yongqiang, HAO Shuxian, CEN Jianwei, HUANG Hui, LI Laihao. Comparison of carbazole method and phloroglucinol method for chondroitin sulfate determination[J]. South China Fisheries Science, 2012, 8(6): 65-71. DOI: 10.3969/j.issn.2095-0780.2012.06.010 |
[6] | ZHU Shichao, QIAN Zhuozhen, WU Chengye. Determination of 7 macrolide antibiotic residues in aquatic products by HPLC-MS/MS[J]. South China Fisheries Science, 2012, 8(1): 54-60. DOI: 10.3969/j.issn.2095-0780.2012.01.009 |
[7] | HUANG Chunli, HUANG He, LIU Wenxia, GAO Ping, HUANG Guofang, LI Zhiqing, CHENG Hong, LUO Lin. Research progress on residual toxicity and detection methods of melamine[J]. South China Fisheries Science, 2011, 7(3): 76-80. DOI: 10.3969/j.issn.2095-0780.2011.03.014 |
[8] | CEN Jianwei, LI Laihao, YANG Xianqing, WEI Ya, ZHAO Suhui, ZHOU Wanjun, SHI Hong. Comparison of four determination methods of Alum content in jellyfish product[J]. South China Fisheries Science, 2010, 6(3): 7-11. DOI: 10.3969/j.issn.1673-2227.2010.03.002 |
[9] | YANG Qibin, LI Xiaolan, SUN Miaomiao, WEN Weigeng, HUANG Jianhua. Methods of testing vitality of postlarvae of Penaeus monodon[J]. South China Fisheries Science, 2010, 6(1): 12-18. DOI: 10.3969/j.issn.1673-2227.2010.01.003 |
[10] | MA Haixia, LI Laihao, YANG Xianqing, WU Yanyan, ZHOU Wanjun, DIAO Shiqiang, CHEN Shengjun. Spectrophotometric determination of formaldehyde in aquatic products[J]. South China Fisheries Science, 2008, 4(6): 26-32. |