Abstract: Immune prevention, especially developing new effective vaccine, is important in preventing and controlling streptococcosis outbreak in tilapia. Currently, the developing sreptococcosis vaccines for tilapia include inactivated vaccine, attenuated vaccine, subunit vaccine, DNA vaccine, passive immunization vaccine, etc.. However, the inoculating way, adjuvants, physiological status of fish and environment factors also have great impact on the effects of vaccine. The paper reviews the research progress on vaccines of streptococcosis in tilapia, so as to provide scientific solutions for the design and application of those vaccines.