李运彩, 张松林, 白芳铭, 赵国庆, 陈粉丽. 氯代苯和烷基酚类化合物斑马鱼毒性的定量构效关系分析[J]. 南方水产科学, 2010, 6(3): 19-23. DOI: 10.3969/j.issn.1673-2227.2010.03.004
引用本文: 李运彩, 张松林, 白芳铭, 赵国庆, 陈粉丽. 氯代苯和烷基酚类化合物斑马鱼毒性的定量构效关系分析[J]. 南方水产科学, 2010, 6(3): 19-23. DOI: 10.3969/j.issn.1673-2227.2010.03.004
shu
 LI Yuncai, ZHANG Songlin, BAI Fangming, ZHAO Guoqing, CHEN Fenli. QSAR analysis of toxicity of chloro-benzene and alkylphenolic compounds to zebrafish[J]. South China Fisheries Science, 2010, 6(3): 19-23. DOI: 10.3969/j.issn.1673-2227.2010.03.004
Citation:  LI Yuncai, ZHANG Songlin, BAI Fangming, ZHAO Guoqing, CHEN Fenli. QSAR analysis of toxicity of chloro-benzene and alkylphenolic compounds to zebrafish[J]. South China Fisheries Science, 2010, 6(3): 19-23. DOI: 10.3969/j.issn.1673-2227.2010.03.004
shu

氯代苯和烷基酚类化合物斑马鱼毒性的定量构效关系分析

QSAR analysis of toxicity of chloro-benzene and alkylphenolic compounds to zebrafish

    摘要
  • 摘要: 文章以ISO推荐使用的标准化鱼类毒性实验动物斑马鱼（Brachydanio rerio）为试验材料，选取10种典型氯代苯和烷基酚类化合物为研究对象进行了毒性试验。将斑马鱼毒性数据（－lg LC50）与受试物参数（2XV、lg P）在SPSS 13.0中进行回归分析，建立回归模型，可认为氯代苯毒性与2XV、烷基酚毒性与lg P之间均存在显著的线性关系，简要分析了其存在的不同致毒机理。

     

    Abstract: In this paper, adult zebrafish (Brachydanio rerio) which was recommended by the ISO standardization for testing fish toxicity was exposed to 10 kinds of chloro-benzene and alkylphenolic compounds. Their toxic effects were assessed in the toxicity test. Through multi-stepwise regression in SPSS 13.0 with the toxicity data (－lg LC50) and the molecular parameters (2XV, lg P), two regression equations were obtained. The results showed that there was significant linear relation between chloro-benzene toxicity and 2XV as well as alkylphenol toxicity and lg P. Furthermore, their toxicity mechanisms were discussed briefly.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回