Abstract: With the rapid development of aquaculture and its intensive extensively expansion, resulting in large-scale occurrence of aquatic animals' diseases, the water polluted is one of the most important reasons. This paper reviewed several kinds of bio-control techniques, such as microecological agents,photosynthetic bacteria, hydrophyte and macroalga, displayed their respective water purificational effects in aquaculture. Culturists can select randomly on the basis of aquaculture conditions and make good use of it, in order to achieve water purification and improve the further development of healthy aquaculture.