Abstract: Grass carp hemorrhagic disease is a severe disease that affect the grass carp breeding. In the past several decades, progress has been made in the research of grass carp hemorrhagic disease in China. The most important advances about GCRV including the biochemical and ultra-structural characteristics of GCRV, the molecular biology research advance, the current strategies on diagnosis and control of GCRV. Here we review these progress and put forward the questions we should resolve in the future, hoping to enhance the productivity of grass carp breeding.