Abstract: We studied the accumulation kinetic characteristics of No.0 diesel and South China Sea Liuhua crude oil in the mussles and viscera of Ruditapes philippinarum based on the two-compartment model.By the nonlinear curve fitting analysis with OriginPro 8.5, we obtained the kinetic parameters of No.0 diesel and South China Sea Liuhua crude oil, including uptake rate constant (k₁), elimination rate constant (k₂), accumulation factor (BCF), theoretical equilibrium concentration (C_Amax) and biological half-life (B_1/2).The results show that for No.0 diesel oil in R.philippinarum, the ranges of k₁, k₂, BCF, C_Amax and B_1/2 were 0.921~9.74, 0.092 8~0.134, 6.87~94.56, 17.18~67.62 mg · kg^-1 and 5.17~7.47 d, respectively; while for the accumulation of South China Sea Liuhua crude oil, the ranges of k₁,  k₂, BCF, C_Amax and B_1/2 were 3.43~64.2, 0.100~0.189, 34.30~379.88, 30.38~595.24 mg · kg^-1 and 3.67~6.93 d, respectively.It is found that k₁ and BCF of R.philippinarum decreased with the increase of petroleum hydrocarbons exposure concentration.However, k₂ and B_1/2 were not significantly related with the concentration of petroleum hydrocarbons in ambient seawater.By comparing the accumulation process of two oils in two tissues of R.philippinarum, we conclude that the accumulation ability of South China Sea Liuhua crude oil is stronger than that of No.0 diesel oil, and the accumulation ability of viscera is stronger than that of mussles.