Abstract: We collected the sediment and water samples from breeding areas, farming areas and non-farming areas outside Liusha Bay quarterly during May, 2012 to January, 2013, and determined the total organic carbon (TOC), total nitrogen (TN) and total phosphorus (TP) content in the sediment, as well as dissolved oxygen (DO) and temperature (T) in the bottom water, hydrodynamically analyzing the distribution characteristics of C, N, P and their pollution. The results indicate that the physical terrain of Liusha Bay determined the slow flow of water inside the bay and the slow water exchange between inner and outer parts of the bay. The DO in bottom water significantly rose from spring to winter and reached the maximum. The DO in bottom water in inner bay was lower than that in outer bay. The TOC and TP contents in surface sediment had no significant seasonal changes, but the TN contents in spring and summer were obviously higher than those in autumn and winter. The TOC and TN contents in the sediment of the breeding areas were significantly higher than those in the non-breeding area, being the highest in the inner bay. The TP content showed no significant time and spatial difference. The annual average pollution indices for TOC, TN and TP were 1.29, 2.98 and 0.92, respectively, which indicated that the bay had suffered medium organic carbon pollution and low nitrogen pollution, and current aquaculture status had significantly accelerated eutrophic sedimentation in Liusha Bay.