Abstract: To explore the growth promotion mechanism of plant extract from grape (Vitis amurensis) seed and sweet wormwood on Monopterus albus, 2 400 healthy eel fingerlings were randomly divided into five groups.We fed control group with basal feed, and four experimental groups with diets containing respectively 10 g·kg^-1, 20 g·kg^-1, 30 g·kg^-1, 40 g·kg^-1 mixture, which were extracted from grape seed and from sweet wormwood(Artemisia annua) with a four-to-one proportion.We determined the digestive enzyme activities and blood biochemical parameters of five eel groups after feeding for 100 d in 21~28℃.Results show that basal diets with the mixture could improve digestive enzyme, blood glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT)′s activities, and total protein (TP)′s content; and could reduce blood glucose (GLU) and triglyceride (TG)′s contents of eel.Compared with the control group, the above indexes had significant difference (P < 0.05) when the dosage of the plant extract was 20 g·kg^-1 or 30 g·kg^-1, while the above indexes had no significant difference (P > 0.05) when it was 10 g·kg^-1or 40 g·kg^-1.There was no significant difference between 20 g·kg^-1 and 30 g·kg^-1 experimental groups.In conclusion, extract from grape seed and sweet wormwood with a four-to-one ratio, when mixed in diets with dosage 20~30 g·kg^-1, could increase digestive enzyme activities, regulate blood biochemical parameters, enhance the digestion and metabolic activity of 3 main nutritive materials and improve the growth of fish.