虾苗使用呋喃西林和呋喃唑酮的残留评估

Assessment of nitrofurazone and furazolidone residues in shrimp seedling

摘要: 使用质量浓度为1 mgL-1的呋喃西林和呋喃唑酮，以混饲的方式对凡纳滨对虾（Penaeus vannamei）幼苗给药，研究呋喃西林和呋喃唑酮在凡纳滨对虾苗体内的代谢和消除规律，对药物的残留时间和残留量等进行风险评估。呋喃西林在凡纳滨对虾幼苗体内的消除速率常数（ke）为0.041 h-1，消除半衰期（t1/2ke）为17.091 h，其代谢物氨基脲（SEM）在50 d后未检出；呋喃唑酮的ke为0.045 h-1，t1/2ke为15.258 h，其代谢物3-氨基-2-恶唑烷基酮（AOZ）在20 d内已低于方法检测限。结果表明，在凡纳滨对虾培苗期，以此试验方式使用呋喃西林和呋喃唑酮不会导致其在成虾体内的残留。

Abstract: In order to study the metabolism and disposition of nitrofurazone and furazolidone in Penaeus vannamei seedling and assess the risks of their residual time and amount, we fed the shrimp seedling with nitrofurazone and furazolidone at concentration of 1 mgL-1.The ke of nitrofurazone is 0.04 h-1 and tl/2ke is 17.091 h for the shrimp seedling, and its metabolite SEM can be eliminated completely within 50 d. The ke of furazolidone is 0.045 h-1 andtl/2ke is 15.258 h, and the concentration of its metabolite AOZ is lower than the LOD within 20 d. The results indicate that use of nitrofurazone and furazolidone in shrimp seedlings cultivation with a therapeutic dose will not lead to residues in adult shrimp.