Abstract: Wailingding waters of the Pearl River Estuary have always been an important traditional fishing ground and migration channel for fishery resources. In recent years, great changes have taken place in habitats under the dual pressure of human activities and climate change. In order to deeply understand the seasonal variation of fishery resources, based on the survey data of the marine ranching in Wailingding waters in 2020 and 2021, we applied the spatial analysis method to explore the seasonal dynamics and characteristics distribution of different catch species, and summarized the fishing ground center of gravity. The results show that the total resource density in spring was higher than that in autumn, distributing in a patchy pattern. In spring, the center of gravity of the fishing ground were concentrated in the southern waters, but moved northwestward in autumn. The density distribution of fish resources was similar to that of total resources. In spring, the center of gravity of fish resources was located in the southwest direction, but moved northwestward in autumn. The resource density of crabs in spring was relatively uniform and increased in autumn, and high-density sea areas increased, distributing in a flaky pattern, and the center of gravity of resources moved from west to northeast. The resource density of shrimps in spring was lower than that in autumn, and the center of gravity of resources moved northeastward. The resource density of mantis shrimps was low and the center of gravity of resources was located in the western sea area in spring, but moved northeastward in autumn. The resource density of cephalopoda in spring was higher than that in autumn, distributing in a flaky pattern, and the center of gravity of resources moved from east to west.