Abstract: To investigate the adaptability of salinity stress of Strombus luhuanus, we studied the effects of different salinities 17, 22, 27, 32 (control group) and 37 on the oxygen consumption rate, ammonia excretion rate and immune-related enzyme activities of S. luhuanus by hydrostatic method. The results indicate that the oxygen consumption rate and ammonia excretion rate in the control group were significantly higher than those in the other groups (P<0.05). The activity of total superoxide dismutase showed no difference (P>0.05). Compared with the control group, the catalase activity in hepatopancreas groups increased to varying degrees, while the catalase activity in muscle groups was not significantly different (P>0.05). The peroxidase activities of hepatopancreas in the control group, salinity 27 and 37 groups were significantly higher than those in salinity 17 and 22 groups (P<0.05). The peroxidase activities of muscle in the experimental groups were significantly higher than that in the control group (P<0.05). The lysozyme activities of hepatopancreas and muscle in the control group were significantly higher than those in the other experimental groups (P<0.05). In summary, the oxygen consumption rate, ammonia excretion rate and activities of immune-related enzyme have significant effects on S. luhuanus under salinity stress.