Abstract: The acute toxicities of trichlorfon, cypermethrin and avermectins to juvenile snail of Babylonia areolata were studied with method of semistatic water. The results show that the 24 h LC₅₀′s of trichlorfon, cypermethrin and avermectins were 210.54 mg·L^-1, 32.52 mg·L^-1 and 8.13 mg·L^-1, respectively, while 48 h LC₅₀′s were 93.52 mg·L^-1, 16.90 mg·L^-1 and 3.96 mg·L^-1, respectively. The order of lethality was trichlorfon> cypermethrin> avermectins, and their safe concentrations (SC) to juvenile snails of B.areolata were 5.54 mg·L^-1, 1.37 mg·L^-1 and 0.28 mg·L^-1, respectively. It is concluded that they all can be used in breeding of B.areolata, but considering environmental impact and drug residues, they should not be abused in practical application.