Abstract: Quorum sensing (QS) is a mechanism of regulating microbial colony behavior, by which bacteriaapperceives signal molecule density outside the cell to regulate a range of important biological functions such as biological luminescence, plasmid transfer, antibiotic production, biofilm formation and virulence factor expression. The paper reviews the mediation functions and several main quenching mechanisms of bacterial QS so as to help develop novel technology of ecological prevention and disease control based on bacterial QS for target, and provide new thoughts for the studies of bacterial QS and development of QS inhibitors with potential application value.